There are several things to do if the speed of the Emacs environment is a problem:
prolog.el and
sicstus-support.el are compiled, i.e. that there is a
prolog.elc and a sicstus-support.elc file at the same
location as the original files. To do the compilation, start Emacs
and type M-x byte-compile-file <RET> path <RET>,
where path is the path to the *.el file. Do not be alarmed
if there are a few warning messages as this is normal.  If all went
well, there should now be a compiled file, which is used the next time
Emacs is started.
     prolog-use-prolog-tokenizer-flag to nil. This means that
Emacs uses built-in functions for some of the source code parsing,
thus speeding up indentation. The problem is that it does not handle all
peculiarities of the Prolog syntax, so this is a trade-off between
correctness and speed.
     prolog-parse-mode variable also affects
the speed, 'beg-of-line being faster than  'beg-of-clause.